CORRELATION BETWEEN SIGNS OF TOXICITY AND CHOLINESTERASE LEVEL OF BRAIN AND BLOOD DURING RECOVERY FROM DI-ISOPROPYL FLUOROPHOSPHATE (DFP) POISONING

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Abstract
Following the injn. of 1 or 2 mg./kg. di-isopropyl fluorophosphate (DFP) subcut. in white rats, nonspecific plasma cholinesterase regenerates more rapidly than the specific cho-linesterases of the red blood corpuscles and the brain. A lag in regeneration of erythrocyte cholinesterase activity lasting from 24 to 48 hrs. occurs following the injn. of DFP, a period during which brain cholinesterase regenerates rapidly. Subsequently, the rate of regeneration of erythrocyte cholinesterase becomes more rapid and surpasses that of the brain. A close relation appears to exist between the severity of the toxic signs of DFP poisoning and the time of brain cholinesterase during the regeneration period. The relation between toxic signs and erythrocyte cholinesterase activity is less exact and fails altogether in the case of the plasma. It is suggested that brain cholinesterase plays an important role in the normal animal in the maintenance of nervous activity and the depressions in brain cholinesterase activity are accompanied by corresponding alterations in the function of the central nervous system.

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