Effects of U-50,488H, a κ-opioid receptor agonist, on the learned helplessness model of depression in mice

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Abstract
We investigated the effects of U-50,488H, a κ-opioid receptor agonist, on the learned helplessness model of depression in mice. Mice pre-exposed to inescapable electric footshock were treated with U-50,488H. Stimulation of the κ-opioid receptor by U-50,488H (10 mg/kg/day, i.p.) attenuated the escape failure induced by pre-exposure to shock. This attenuation by U-50,488H was blocked by MR2266 (10 mg/kg/day, s.c.), an opioid receptor antagonist. These results suggest that the κ-opioid system plays an important role in the learned helplessness depression in mice.

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