Interaction of drugs with bile components. I. Effects of bile salts on the dissolution behavior of indomethacin and phenylbutazone.

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Abstract
The effects of bile salts on the dissolution behavior of the non-steroidal antiinflammlatory drugs indomethacin and phenylbutazone were studied. Bile salts such as sodium desoxycholate and sodium cholate considerably enhanced the dissolution of both drugs in pH 7.3 buffer at 37.degree. C. The enhancement of the dissolution of indomehacin in the presence of bile salts was mainly due to micellar solubilization. The enhanced dissolution of phenylbutazone may be due to the wetting effect, increasing the effective surface area of the powder.