Genotyping for human platelet‐specific antigens HPA‐1, ‐2, ‐3, ‐4 and ‐5 in the Slovenian population reveals a slightly increased frequency of HPA‐1b and HPA‐2b as compared to other European populations

Publisher Website
Google Scholar
Abstract
Typing of human platelet alloantigens (HPA) is necessary in various clinical situations. The purpose of this study was to type a random sample of the Slovenian population for HPA alleles, in order to obtain genetic population data. A total of 152 unrelated Slovenian blood donors were genotyped for HPA‐1, ‐2, ‐3, ‐4 and ‐5 alleles using a simple method that enables simultaneous and complete determination of HPA genotypes. Ten different polymerase chain reactions employing sequence‐specific priming (PCR‐SSP), which worked in identical cycling conditions, were used. The allele frequencies were 0.809 for HPA‐1a, 0.191 for HPA‐1b, 0.891 for HPA‐2a, 0.109 for HPA‐2b, 0.591 for HPA‐3a, 0.407 for HPA‐3b, 0.997 for HPA‐4a, 0.00 for HPA‐4b, 0.934 for HPA‐5a and 0.066 for HPA‐5b. When compared to results of studies of various other Caucasian populations, our population displayed a slightly but not significantly higher proportion of the HPA‐1b and 2b alleles.