A new model for testing therapeutic interventions during myocardial ischemia
- 1 June 1983
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Die Gesamte Experimentelle Medizin
- Vol. 182 (2) , 149-152
- https://doi.org/10.1007/bf01851120
Abstract
An open-chest dog heart model is presented which shows highly reproducible hemodynamic, electrophysiologic, and metabolic changes during and after short-term coronary occlusions. We repeatedly performed 3-min coronary ligations of the proximal ramus interventricularis anterior followed by reperfusion periods of 45 min. Thus, hemodynamic, metabolic, and electrophysiologic parameters of myocardial damage were fully reversible. The experimental model presented seems well suited to evaluate interventions which aim at influencing the extent and damage of myocardial ischemia without needing a large number of separate experiments.This publication has 7 references indexed in Scilit:
- Experimental validation of methods for the measurement of coronary sinus blood flow in manBasic Research in Cardiology, 1979
- Biochemical and morphological correlates of acute experimental myocardial ischemia in the dog. IV. Energy mechanisms during very early ischemia.Circulation Research, 1979
- Initial myocardial adjustments to brief periods of ischemia and reperfusion in the conscious dog.Circulation Research, 1978
- Persistence of myocardial injury following brief periods of coronary occlusionCardiovascular Research, 1976
- Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.Journal of Clinical Investigation, 1975
- Factors Influencing Infarct Size Following Experimental Coronary Artery OcclusionsCirculation, 1971