Delayed Contact Sensitivity to Catechols

Abstract
Summary: Catechol as well as the 3-n-alkylcatechols, were shown to be equally good in inducing delayed contact sensitivity in guinea pigs since the majority of animals injected became sensitive. Consequently the capacity to induce sensitization, as measured by the percentage of animals becoming sensitive, is unrelated to the structure of the 3-n-alkylcatechols. The degree of sensitivity induced as well as cross-reactivity depended upon the length of the 3-n-alkyl side-chain. Thus the degree of sensitivity induced is strongly dependent on the structure of the sensitizer (in this instance chain length) and largely independent of sensitizing dose. The data obtained suggested that it was possible to estimate the maximum length of the antigenic determinant. The dermal toxicity of the alkylcatechols was shown to be unrelated to their sensitizing capacity.

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