BIOSYNTHESIS OF THE CHONDROITIN SULFATE-PROTEIN LINKAGE REGION: PURIFICATION AND PROPERTIES OF A GLUCURONOSYLTRANSFERASE FROM EMBRYONIC CHICK BRAIN
- 1 September 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (1) , 374-380
- https://doi.org/10.1073/pnas.64.1.374
Abstract
The present paper describes the purification and properties of a glucuronosyltransferase isolated from 13-day embryonic chick brain. The enzyme catalyzes transfer of glucuronic acid from UDP-glucuronic acid to a series of low and high molecular weight compounds which contain terminal non-reducing beta-D-galactose residues. Studies utilizing enzymatically degraded chondromucoprotein as acceptor suggest that the glucuronosyltransferase terminates biosynthesis of the linkage region between protein and polysaccharide of chondromucoprotein.Keywords
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