EFFECT OF TEMPERATURE ON CHANGES, INDUCED BY OESTRUS, in α‐ AND β‐ADRENOCEPTOR ACTIVITIES OF THE RAT UTERUS

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Abstract
The α- and β-adrenoceptor activities of the isolated rat uterus during the oestrous cycle were influenced greatly by temperature changes. During dioestrus, lowering the bath temperature to 25° C from 40° C increased two-fold the inhibition produced by (–)-adrenaline, (–)-noradrenaline, (–)-phenylephrine and (–)-isoprenaline. During oestrus adrenaline, noradrenaline and phenylephrine produced biphasic responses of contraction followed by inhibition at 40° C and isoprenaline produced only inhibition. At 25° C the contractile α-responses either were abolished (phenylephrine) or greatly reduced (adrenaline and noradrenaline), while the inhibitory β-effects of all four amines were increased.