Effects of Sustained-Release Bupropion and Supportive Group Therapy on Cigarette Consumption in Patients With Schizophrenia
- 1 April 2001
- journal article
- clinical trial
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 158 (4) , 635-637
- https://doi.org/10.1176/appi.ajp.158.4.635
Abstract
The study examined the efficacy, tolerability, and safety of supportive group psychotherapy and adjunctive sustained-release bupropion for nicotine addiction in patients with schizophrenia. Eight patients participated in a 14-week open-label trial. End expired breath carbon monoxide level, symptom levels, neuropsychological performance, and suppression of the P50 event-related potential were measured before and after the 14-week trial. Patients showed a decrease in carbon monoxide levels that was not associated with any worsening in symptom, neuropsychological, or P50 suppression measures. Use of sustained-release bupropion in combination with supportive group therapy may help patients with schizophrenia decrease their cigarette consumption.Keywords
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