Dehydroepiandrosterone, pregnenolone and sexsteroids down‐regulate reactive astroglia in the male ratbrain after a penetrating brain injury
- 24 March 1999
- journal article
- Published by Wiley in International Journal of Developmental Neuroscience
- Vol. 17 (2) , 145-151
- https://doi.org/10.1016/s0736-5748(98)00065-3
Abstract
Astrocytes are a target for steroid hormones and for steroids produced by the nervoussystem (neurosteroids). The effect of gonadal hormones and several neurosteroids in theformation of gliotic tissue has been assessed in adult male rats after a penetrating wound of thecerebral cortex and the hippocampal formation. The hormones testosterone, 17β‐estradiol and progesterone and the neurosteroids dehydroepiandrosterone, pregnenolone andpregnenolone sulfate resulted in a significant decrease in the accumulation of astrocytes in theproximity of the wound and in a decreased bromodeoxyuridine incorporation in reactiveastrocytes. Of all steroids tested, dehydroepiandrosterone was the most potent inhibitor of gliotictissue formation. These findings suggest that neurosteroids and sex steroids may affect brainrepair by down‐regulating gliotic tissue.Keywords
Funding Information
- Comunidad de Madrid (08.5/0009/1997)
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