Lipase-Catalyzed Synthesis of Optically ActiveN,N,N,-Trimethylethanaminium α-Tocopherol Analog MDL-73404
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (11) , 929-930
- https://doi.org/10.1055/s-1994-23051
Abstract
Optically active 3,4-dihydro-6-hydroxy-N,N,N,2,5,7,8,-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate MDL-73404 was synthesized by kinetic resolution of racemic chromanethanols with lipase. The unnecessary (R)-chromanethanol as by-product of resolution was inverted to the (S)-isomer that could be treated as substrate for repeated lipase-catalyzed resolution.Keywords
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