Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin

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Abstract
The phospholipid PAF‐acether is released from a range of inflammatory cell types and, in experimental animals, has properties appropriate to a mediator of inflammation. We have studied the inflammatory characteristics of intradermally injected PAF‐acether in human skin. An early weal and flare response was succeeded, in a proportion of subjects, by an area of late‐onset erythema at the site of the resolved weal, reminiscent of the dual response to allergen in sensitized individuals. The tim‐course and dose‐response relationship of the early response has been determined and a synergistic interaction between PAF‐acether and prostaglandin E2 established. PAF‐acether should therefore be considered as a potential mediator of both acute and persisting inflammation in man.