Selection of Cell Populations in Induction of Tolerance: Affinity of Antibody Formed in Partially Tolerant Rabbits
Open Access
- 1 January 1968
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 100 (1) , 138-141
- https://doi.org/10.4049/jimmunol.100.1.138
Abstract
Summary: Induction of partial tolerance to a haptenic determinant, by the neonatal injection of antigen, resulted in a decrease in the affinity of the antibody formed. Thus, tolerance was more readily induced in those cells capable of synthesizing high affinity as opposed to low affinity antibody. The results are interpreted in terms of a thermodynamically driven selection of cell populations participating in immunologic reactions.This publication has 1 reference indexed in Scilit:
- Variations in Affinities of Antibodies during the Immune Response*Biochemistry, 1964