Nonosmolar Factors Affecting Renal Water Excretion

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Abstract
(First of Two Parts)THE pioneering work of Verney and his co-workers1 defined a very delicate mechanism that maintains the constancy of the osmotic pressure of body fluids by regulating the release of vasopressin. These investigators clearly showed that an increase in plasma osmotic pressure as small as 1 to 2 per cent by the intracarotid injection of hypertonic saline causes the release of an amount of vasopressin capable of dramatically decreasing renal water excretion.1 Conversely, the injection of a hypotonic solution into the carotid circulation has been shown to cause a prompt diuresis.2 These results have been used to . . .

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