Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice
- 1 February 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 15 (2) , 159-161
- https://doi.org/10.1093/carcin/15.2.159
Abstract
Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.Keywords
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