New Antimicrobial Filicinic Acid Derivatives from Hypericum drummondii
- 1 September 1991
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 54 (5) , 1314-1320
- https://doi.org/10.1021/np50077a013
Abstract
Bioactivity-guided fractionation of the hexane extract of the stems and leaves of Hypericum drummondii has afforded four new filicinic acid derivatives: drummondin D, isodrummondin D, drummondin E, and drummondin F. The structures of these compounds were established by spectroscopic methods. All compounds possessed strong antibiotic activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and the acid fast bacterium Mycobacterium smegmatis.Keywords
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