Unbalanced globin chain synthesis by Hb lincoln park (anti‐lepore) reticulocytes

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Abstract
Hemoglobin synthesis was studied in vitro in reticulocytes from a patient with the anti‐Lepore variant Hb Lincoln Park. Incorporation of L‐leucine‐3H into the α and βδ chains of Hb Lincoln Park was substantially less than the incorporation into the corresponding globin chains of Hb A, with the rate of synthesis of the βδ chain being similar to that of the δ chain of Hb A2. Synthcis of the a and total non‐α globin components was unbalanced, with a substantial excess of α chain synthesis. These findings help to explain the mild hemolytic disease present in individuals with this hemoglobin variant.