EFFECT OF VEHICLE ON PILOCARPINE‐INDUCED MIOSIS

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Abstract
To determine the effect of 1.4% polyvinyl alcohol (PVA) and castor oil vehicles on the pilocarpine-induced miosis, the miotic effect of 2% pilocarpine-PVA and oily drops on 4 young and 10 elderly people was studied and the miotic effect of 4% pilocarpine-PVA and oily drops on 13 elderly people was studied. The miosis developed fast within 15 min, and maximum miosis was reached within 1 h. Oily drops of pilocarpine induced stronger maximum miosis than corresponding PVA-drops. The pupil remained contracted to less than 50% of its starting diameter after pilocarpine-PVA drops for 3-4 h and after oily drops for 9 h and returned to its starting diameter after pilocarpine-PVA drops 9-10 h and after oily drops 20-24 h following administration. The difference in the effect between pilocarpine-PVA and oily drops was independent of the subjects'' age.

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