Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells
Open Access
- 1 November 1989
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 98 (3) , 717-720
- https://doi.org/10.1111/j.1476-5381.1989.tb14597.x
Abstract
Pretreatment of bovine aortic smooth muscle cells in culture with pertussis toxin (PT) or cholera toxin (CT) potentiated the synthesis of prostacyclin (PGI2) induced by 5-hydroxytryptamine (5-HT) and phorbol-12-myristate, 13-acetate (PMA). The production of PGI2 by explants from the bovine aortic media was also synergistically stimulated by 5-HT and CT, whereas PT was inactive. These data are consistent with the hypothesis that guanosine 5′-triphosphate binding proteins are directly involved in the control of phospholipases which release free arachidonic acid for prostaglandin synthesis.This publication has 15 references indexed in Scilit:
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