Bioenergetics of acute vasogenic edema

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Abstract
The bioenergetic mechanisms of vasogenic edema were studied by measuring concentrations of ATP, phosphocreatine (CrP) and lactate in rapidly frozen edematous white matter in cats. When edema was produced using a cold lesion, ATP and CrP were reduced to 1/2 of control values and lactate was elevated. A correction was applied for dilution; high-energy phosphates were equal to control values and lactate was more significantly elevated. This pattern contrasted with that seen in white-matter ischemia in which CrP is depressed out of proportion to ATP. The white-matter lactate concentration in the plasma infusion model of edema was increased. Vasogenic edema induces an increase in lactate but does not deplete high-energy phosphate compounds in affected white matter.