Application of the Horner-Wadsworth-Emmons Reaction to the Functionalization of Dendrimers: Synthesis of Amino Acid Terminated Dendrimers
- 1 October 1997
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1997 (10) , 1199-1207
- https://doi.org/10.1055/s-1997-1332
Abstract
The Horner-Wadsworth-Emmons reaction of the first, third and fourth generation of aldehyde terminated dendrimers 1-[Gn] (n=1: 6 CHO, n=3:24 CHO, n=4:48 CHO groups, respectively) with phosphonates unsubstituted at the carbon α to the phosphoryl group 2a-i affords in moderate yield dendrimers bearing various α,β-unsaturated functional groups on the surface, including amino acid derivatives.Keywords
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