BINDING OF ANDROGEN TO COMPONENTS OF RAT VENTRAL PROSTATE NUCLEI IN VITRO

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Abstract
Following incubation of rat ventral prostate slices with [1,2-3H]testosterone in vitro, radioactive material is found to be associated with the nuclei. Sodium chloride extraction of the nuclei removes macromolecules which might at least partially be responsible for this association. These macromolecules are probably components of the nuclear chromatin. Analyses of the radioactive material indicate that the major portion consists of dihydrotestosterone* and to a lesser extent of testosterone. All the radioactive material is linked non-covalently to the nuclear components responsible for the association.

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