Diagnostic value of bone marrow iron deposits in idiopathic hemochromatosis

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Abstract
The stainable Fe content of bone marrow of 4 patients with documented idiopathic hemochromatosis was reviewed. There was a moderate increase in hemosiderin deposits in each case, but the striking difference in the morphologic appearance of these deposits was more important. These consisted of small, uniform, closely packed granules that may be readily distinguished from bone marrow Fe found in normal persons and in persons with other disorders. This should serve as an additional simple diagnostic aid in patients with idiopathic hemchromatosis.