Is benign rolandic epilepsy genetically determined?
- 28 June 2004
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 56 (1) , 129-132
- https://doi.org/10.1002/ana.20153
Abstract
Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0–0.4) for BRE compared with 0.7 (95% CI, 0.5–0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored. Ann Neurol 2004;56:129–132Keywords
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