Firing Pattern of Cells in Human Thalamus during Dorsal Column Stimulation

Abstract
The effect of dorsal column stimulation (DCS) on single cell activity of the thalamus was analyzed in a patient who underwent stereotaxic thalamotomy following implantation of a dorsal column stimulator. Nine thalamic units were monitored long enough for an adequate evaluation of the effect of repeated DCS upon spontaneous thalamic activity. The units’ firing frequency decreased significantly during DCS and decreased even further following cessation of the stimulation. These data, even if obtained from a small cell population, extend to the cellular level in the human thalamus the previous observations that DCS exerts marked effects on supraspinal structures.

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