Vesicular Stomatitis Virus Maturation Sites in Six Different Host Cells

Abstract
Six different cell types, L, Vero, HeLa, BHK21, PK(H13) and CF, were infected with vesicular stomatitis virus. A minimum of 100 individual virus-containing cells of each type was scored for the sites of viral maturation as observed by electron microscopy of thin sections. The principal site of viral maturation was the intracytoplasmic vacuolar membranes for PK(H13) and the plasma membrane for L and Vero cells. Both types of membranes served as sites for HeLa and BHK21 cells. It is concluded that the site of maturation of vesicular stomatitis virus is a host-dependent phenomenon.

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