MENTAL-RETARDATION ASSOCIATED WITH BALANCED CHROMOSOME REARRANGEMENTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (2) , 136-141
Abstract
Balanced chromosome rearrangements were found in 7 of 455 retarded children vs. 4 of 1679 nonretarded, psychiatric children (P < .05). The combined incidence of non-Robertsonian balanced rearrangements from this and reported surveys of the mentally retarded was 5 times greater than that from newborn surveys, whereas Robertsonian translocations were not increased among the retarded. The combined data show an increase in de novo rather than familial rearrangements among the retarded; the increase in de novo rearrangements is specifically for non-Robertsonian translocations.