Gastrointestinal Polyposis with Mucocutaneous Pigmentation (Peutz–Jeghers Syndrome)

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Abstract
THE syndrome of familial gastrointestinal polyposis associated with pigmentation of the skin and mucous membranes was described by Peutz1 in 1921, but only during the last six years has its comparative frequency been generally recognized. Since Jeghers et al.2 gave their masterly account of 10 patients suffering from this condition more than 60 cases have been recorded, and several "probable" and "possible" cases brought to light from the medical, surgical and dermatologic literature of the past sixty years.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 The poor recognition of the syndrome makes an accurate estimate of its prevalence still impossible, but the fact that several observers, aware . . .