An Evaluation of Isocitric Dehydrogenase in Liver Disease
- 1 October 1961
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 55 (4) , 604-609
- https://doi.org/10.7326/0003-4819-55-4-604
Abstract
Laboratory evaluation of hepatocellular damage has been aided in recent years by the development of new methods for measuring serum activities of enzymes released from injured liver cells. One of these enzymes is isocitric dehydrogenase; in the Kreb's cycle, this enzyme catalyzes the dehydrogenation and decarboxylation of isocitrate to alpha-ketoglutarate (1). The method for the determination of serum isocitric dehydrogenase offers some technical advantages when it is compared with the spectrophotometric methods for the serum transaminases [glutamic-oxaloacetic and glutamic-pyruvic transaminases] (2). Furthermore, although the liver and the myocardium show comparable activities of isocitric dehydrogenase, increased activity of this enzyme inKeywords
This publication has 3 references indexed in Scilit:
- Measurement of Isocitric Dehydrogenase Activity in Body FluidsClinical Chemistry, 1959
- ON THE MECHANISM OF THE ACONITASE AND ISOCITRIC DEHYDROGENASE REACTIONSJournal of Biological Chemistry, 1957
- Serum Glutamic Pyruvic Transaminase in Cardiac and Hepatic Disease.Experimental Biology and Medicine, 1956