Differential expression of selected genes in human leukemia leukocytes.
- 1 August 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (15) , 4668-4671
- https://doi.org/10.1073/pnas.79.15.4668
Abstract
CDNA clones complementary to mRNA of cells from patients having chronic lymphocytic leukemia (CLL) were used to examine quantitative changes in the mRNA levels of specific genes in human leukemia leukocytes. Of 400 CLL-positive clones that did not hybridize with placental mRNA, 14 were studied. Three of the 14 clones were highly represented in mRNA from CEM, a T-cell line. One clone was highly represented in mRNA from CLL and 2 were highly represented in mRNA from patients with chronic myelocytic leukemia. Ten clones were not significantly represented in normal leukocytes and spleen mRNA. Several genes that are differentially expressed were identical in human leukemia leukocytes.This publication has 27 references indexed in Scilit:
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