Bilirubin-Induced Modulation of Cerebral Protein Phosphorylation in Neonate Rabbits in Vivo
- 8 October 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 218 (4568) , 156-158
- https://doi.org/10.1126/science.7123226
Abstract
Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.Keywords
This publication has 9 references indexed in Scilit:
- Phosphorylated Proteins as Physiological EffectorsScience, 1978
- Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†Nature, 1976
- Adenosine 3′,5′-Monophosphate-dependent Protein Kinase from Adipose TissuePublished by Elsevier ,1972
- EFFECTS OF PHOSPHODIESTERASE INHIBITORS ON CYCLIC AMP LEVELS AND ON LIPOLYSIS*Annals of the New York Academy of Sciences, 1971
- Phosphorylation of Endogenous Protein of Rat Brain by Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein KinaseJournal of Biological Chemistry, 1971
- THE INFLUENCE OF BILIRUBIN ON OXIDATIVE PHOSPHORYLATION AND RELATED REACTIONS IN BRAIN AND LIVER MITOCHONDRIA: EFFECTS OF PROTEIN‐BINDINGJournal of Neurochemistry, 1966
- Studies of cellular toxicity of unconjugated bilirubin in kernicteric brain.Journal of Clinical Investigation, 1966
- PLASMA BILIRUBIN DETERMINATION IN THE NEWBORN INFANTPublished by American Academy of Pediatrics (AAP) ,1965
- EXPERIMENTAL STUDIES ON THE PATHOGENESIS OF KERNICTERUSPediatrics, 1957