Elevated Urinary Levels of 5-Hybroxyindole Acetic Acid and Its Relationship Among Levels of Plasma Follicle Stimulating Hormone, Testosterone and Testicular Pathology in Patients with Severe Oligospermia and/or Azoospermia

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Abstract
Plasma follicle stimulating hormone [FSH], testosterone and urine 5-hydroxyindole acetic [HIAA] acid levels were measured in 300 patients seen at an andrology clinic. Testicular biopsies were obtained from many of the severely oligospermic or azoospermic patients. Plasma FSH concentrations were related inversely to sperm cell concentration, while plasma testosterone concentrations were depressed as the sperm count decreased to 5 times 106 per ml. The urine levels of 5-HIAA followed the same pattern as FSH and were elevated in the group of individuals with sperm counts less than 10 times 106 per ml. Elevations in 5-HIAA often were associated with abnormalities in the testicular biopsy. Only 30% of the patients who had elevated 5-HIAA also had elevated FSH or depressed testosterone levels. The factors responsible for the elevation in 5-HIAA levels as the sperm count declines remain unclear.