The Taeniacidal Activity of Seven Halogenated Diphenyl Methanes, a Diphenyl Propane and a Diphenyl Ether

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Abstract
2,2[image]-Dihydroxy-5,5[image]-dichlorodiphenyl methane (I), 2,2[image]-dihydroxy-3,3[image] ,5,5[image]-tetrachlorodiphenyl methane (II), 3,3[image] ,4,4[image]-tetrachlorodiphenyl methane (III), 2,2[image]-dihydroxy-3,3[image] ,5,5[image] ,6,6[image]-hexachlorodiphenyl methane (IV), 2,2[image]-dihydroxy-3,3[image] ,4,4[image] ,5,5[image] ,6,6[image]-octachloro-diphenyl ether (V), 3,3[image]-dihydroxy-2,2[image] ,4,4[image] ,5,5[image] ,6,6[image]-octachloro-diphenyl propane (VI), 4,4[image]- dihydroxy-3,3[image] ,5,5[image] ,6,6[image]-hexachloro-diphenyl methane (VII), 4,4[image]-dihydroxy-3,3[image],5,5[image] ,6,6[image]-hexabromo-diphenyl methane (VIII), and 4,4[image]-dihydroxy-3,3[image] ,-5,5[image]-tetra-bromodiphenyl methane (IX) were tested for anthelmintic activity against Raillietina cesticillus by means of the controlled test. Compounds IV and V were the most highly active. The possible importance of the hydroxy group, its position, the number and type of halogen atoms, and the linkage of the phenyl groups relative to the effect on anthelmintic activity is discussed.

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