Adsorption of polymorphonuclear leukocyte lysosomal enzymes to monosodium urate crystals

Publisher Website
Google Scholar
Abstract
Monosodium urate (MSU) crystals induced prompt release of iysozyme, and slower release of β‐glucuronidase, α‐mannosidase, and lactic dehydrogenase (LDH) from polymorphonuclear leukocytes. At increasing crystal concentrations, an increasing delay in the apparent onset of β‐glucuronidase release was detected which appears to be due to selective adsorption of enzyme activities to the MSU crystals: β‐glucuronidase > LDH > α‐mannosidase > lysozyme. Lysosomal enzyme adsorption by MSU crystals may then contribute to experimental error or may modulate gouty inflammation.