SUPPRESSION BY GAMMA-HYDROXYBUTYRIC ACID OF ETHANOL WITHDRAWAL SYNDROME IN RATS
- 1 September 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Alcohol and Alcoholism
- Vol. 24 (5) , 447-451
- https://doi.org/10.1093/oxfordjournals.alcalc.a044940
Abstract
The ability of gamma-hydroxybutyric acid to suppress ethanol withdrawal syndrome was tested in male rats rendered physically dependent on ethanol by several intragastric administrations of ethanol (9–15 g/kg daily for 7 days). Gamma-hydroxybutyrate (0.25, 0.50 and 1.00 g/kg i.p.), administered 8 hr after the last ethanol dose, produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically-induced seizures; the highest dose tested suppressed all ethanol withdrawal symptoms.This publication has 9 references indexed in Scilit:
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