Trichosanthin, α‐momorcharin and β‐momorcharin: identity of abortifacient and ribosome‐inactivating proteins
- 1 March 1988
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 31 (3) , 265-268
- https://doi.org/10.1111/j.1399-3011.1988.tb00033.x
Abstract
The abortifacient proteins trichosanthin, α-momorcharin and β-momorcharin at nM concentrations inhibit cell-free protein synthesis. The momorcharins and the ribosome-inactivating proteins isolated from Momordica charantia seeds cross-react with the respective antisera. The ribosome-inactivating proteins saporins, pokeweed antiviral protein (PAP) and, to a lesser extent, gelonin have abortifacient activity on pregnant mice.Keywords
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