HISTOCHEMICAL CHANGES IN STRIATED-MUSCLE IN PATIENTS WITH INTERMITTENT CLAUDICATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 101  (12) , 658-663
Abstract
Biopsy specimens from the gastrocnemius or rectus femoris muscle of 20 patients with intermittent claudication were studied using fresh frozen cryostat sections and histochemical reactions for ATP, NAD dehydrogenase reductase and phosphorylase and modified Gomori trichrome staining. Neuropathic changes, such as fibertype grouping and small group atrophy, were present to some extent in all of the biopsy specimens. Myogenic muscle changes such as necrosis and phagocytosis were seen in approximately 1/3 and various forms of myofibrillar disorganization in approximately 2/3 of the specimens. The amount and size of the type I aerobic fibers increased with the increasing severity of the ischemic disease.

This publication has 0 references indexed in Scilit: