Intramolecular nucleophilic attack in 7α-aminophenylacetamido-cephalosporin esters
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 1162
- https://doi.org/10.1039/c39720001162
Abstract
7α-Aminophenylacetamido-Δ3-cephalosporin esters cyclize to 3-dihydrothiazinyl-6-phenylpiperazine-2,5-diones by an intramolecular nucleophilic attack of the side-chain α-amino-function while under the same conditions the analogous 6α-aminophenylacetamidopenicillin ester does not cyclize, because of steric hindrance to intramolecular attack.Keywords
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