TOXICITY STUDIES ON TANNIC ACID ADMINISTERED BY ENEMA

Publisher Website
Google Scholar
Abstract
1. Based on the 1 minute forced retention studies, the lowest concentration of a tannic acid or clysodrast containing enema producing liver necrosis was 8 per cent. Based on the extreme condition of a forced 1 hour retention enema, liver damage was detected at the 2.5 per cent level. 2. Colonic "damage" exceeding the resorbable edema and minor inflammation observed in some controls again was a function of dose and contact time. Coagulative necrosis and hemorrhage of colonic tissue, persisting for 72 hours, were seen after 16 per cent tannic acid or clysodrast containing 1 minute enemas and 4 per cent clysodrast containing enemas forcefully retained for 1 hour. Under this condition, liver damage was almost invariably associated with these alterations in colonic mucosa. At the highest levels death occurred in 8 of 22 animals prior to the 24 and 72 hour times of scheduled sacrifice. 3. At the concentrations (0.25 per cent to 2.0 per cent) employed, 3 consecutive 1 minute retention enemas given at half-hour intervals did not produce liver damage in animals sacrificed at 72 hours. 4. There was no detectable difference between the colonic or hepatotoxic effects of clysodrast and tannic acid.

This publication has 1 reference indexed in Scilit: