Incidence of Posttransfusion Hepatitis in Previously Frozen Blood

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Abstract
The incidence of posttransfusion hepatitis was significantly reduced by a transmembrane washing procedure on thawed, deglycerolized, previously frozen red blood cells (RBC). The method constitutes mechanical centrifugation, high glycerol concentration, slow freeze and thaw, and a 4-liter washing procedure for deglycerolization. Four cases of histologically proved hepatitis (one icteric, three anicteric) occurred in a control group of 104 recipients receiving 442 transfusions (median 3) of such RBC resuspended in autologous plasma, an incidence of 9 per 1,000. No hepatitis occurred in the treatment group receiving 623 transfusions (or a median of 4 units per patient) of such RBC resusThe incidence of posttransfusion hepatitis was significantly

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