Studies of Adenoviruses (APC) in Volunteers

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Abstract
The report summarizes the experience of 13 prison studies wherein 654 volunteers were inoculated by various routes with adeno-virus types 1 through 6. The virus types swabbed on the oro-pharynx or instilled into the nares produced infection as indicated by a complement-fixing antibody response predominantly in susceptibles. Two to 4 days following such inoculation nearly 1/3 of the volunteers developed an afebrile naso-pharyn-geal catarrh (common cold) which could not be attributed to the viruses inoculated; it was not significantly associated with the occurrence of infection or with susceptibility as indicated by neutralizing antibody status, and it occurred with nearly equal frequency in non-virus inoculated controls. On the other hand, 2-7 days following the swabbing of adenovirus types 1, 3, 4 or 5 into the conjunctiva, more than 90% of susceptible volunteers developed an illness, chiefly characterized by folli-cular conjunctivitis not infrequently associated with fever and pharyngitis. Illness was significantly associated with demonstrable infection and with susceptibility. Such illness and infection induced by adenovirus type 3 challenge was to a large extent prevented by prophylactic vaccines prepared by heat-or formaldehyde-inactivation of type 3 adenovirus.