Aging and the Generation Cycle of Intestinal Epithelial Cells in the Mouse

Publisher Website
Google Scholar
Abstract
The generation cycle of the crypt cells in the small intestine of the mouse was investigated in the duodenum, jejunum, and ileum in young, middle-aged, and old mice (3, 12, and 31 months of age, respectively) with the aid of tritiated thymidine autoradiography. Two changes that occurred with age were found in the labeled cohort of cells: the generation cycle was lengthened, and the course of the generation cycle of the members of the cohort became more variable. Both these changes occurred in each of the three regions of the small intestine.

This publication has 1 reference indexed in Scilit: