Synthesis and properties of tachyplesin I, a lipopolysaccharide‐binding peptide, from Tachypleus tridentatus

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Abstract
Tachyplesin I, a cationic heptadecapeptide amide containing two disulfide bonds isolated from hemocytes of Tachypleus tridentatus, which binds to lipopolysaccharide, was synthesized by a solid‐phase procedure. Reduction and oxidation of the deprotected peptide amide yielded an identical peptide to native tachyplesin I in terms of chemical and biological properties. Tachyplesin 1 was found to bind to alkylphosphorylcholine accompanied by perturbation of its tyrosyl and tryptophyl residues but bound only weakly to N‐acetyl‐D‐glucosamine tetramer.