Identification of Nudix Hydrolase Family Members with an Antimutator Role in Mycobacterium tuberculosis and Mycobacterium smegmatis
- 15 April 2006
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 188 (8) , 3159-61
- https://doi.org/10.1128/jb.188.8.3159-3161.2006
Abstract
Mycobacterium tuberculosis and Mycobacterium smegmatis MutT1, MutT2, MutT3, and Rv3908 (MutT4) enzymes were screened for an antimutator role. Results indicate that both MutT1, in M. tuberculosis and M. smegmatis , and MutT4, in M. smegmatis , have that role. Furthermore, an 8-oxo-guanosine triphosphatase function for MutT1 and MutT2 is suggested.Keywords
This publication has 30 references indexed in Scilit:
- Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?Journal of Antimicrobial Chemotherapy, 2005
- Multiple Enzyme Activities of Escherichia coli MutT Protein for Sanitization of DNA and RNA Precursor PoolsBiochemistry, 2005
- Structure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans : a Member of the Nudix FamilyJournal of Bacteriology, 2003
- Oxidative nucleotide damage: consequences and preventionOncogene, 2002
- Multidrug-Resistant Tuberculosis in Prison Inmates, AzerbaijanEmerging Infectious Diseases, 2001
- Phosphatidylinositol Is an Essential Phospholipid of MycobacteriaJournal of Biological Chemistry, 2000
- DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence?Molecular Microbiology, 1998
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998
- Cloning, Purification, and Properties of a Novel NADH PyrophosphataseJournal of Biological Chemistry, 1995
- MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesisNature, 1992