Synthesis of [8-Norleucine]Somatostatin-28
- 1 January 1982
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 363 (2) , 1247-1252
- https://doi.org/10.1515/bchm2.1982.363.2.1247
Abstract
Because of the high tendency of natural and synthetic somatostatin-28 to S-oxide formation at methionine-8 via air-oxidation, the 8-norleucine analog was prepared following the synthetic route previously elaborated for the parent methionine peptide. [Nle8]somatostatin-28 was obtained at a high degree of purity as judged by different analytical assays. It possessed the identical stimulatory effect on amylase release from guinea pig pancreatic acini as the natural peptide extracted from porcine intestine.This publication has 6 references indexed in Scilit:
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