Levels of Soluble Cell Adhesion Molecules in Patients With Dyslipidemia
- 1 April 1996
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 93 (7) , 1334-1338
- https://doi.org/10.1161/01.cir.93.7.1334
Abstract
Background Increased expression of cell adhesion molecules (CAMs) on the vascular endothelium has been postulated to play an important role in atherogenesis. Both in vitro and in vivo studies have suggested that dyslipidemia may increase expression of CAMs. Methods and Results To determine whether dyslipidemia is associated with increased expression of CAMs, we examined the levels of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and soluble E-selectin (sE-selectin) in individuals with either hypercholesterolemia or hypertriglyceridemia and in control subjects matched for age and sex. Patients with hypertriglyceridemia had significantly higher levels of sVCAM-1 (739±69 ng/mL) compared with patients with hypercholesterolemia (552±63 ng/mL) and control subjects (480±56 ng/mL). Levels of sICAM-1 were significantly increased in both the hypercholesterolemic and hypertriglyceridemic groups (298±29 and 342±31 ng/mL, respectively) compared with the contr...Keywords
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