Enhancer sequences responsible for DNase I hypersensitivity in polyomavirus chromatin.
Open Access
- 1 June 1986
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 6 (6) , 2249-2252
- https://doi.org/10.1128/mcb.6.6.2249
Abstract
DNase I preferentially cleaves polyomavirus minichromosomes at two sites in the enhancer, each of which comprises the sequence AAGCAPuPuAAG flanked by short inverted repeats. A tandem duplication of this sequence generates an additional hypersensitive locus. Mutations which alter either the AAGCAPuPuAAG or flanking repeats diminish hypersensitivity. This region must determine the chromatin conformation recognized by DNase I.This publication has 31 references indexed in Scilit:
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