INVITRO RADIATION RESPONSE OF CELLS FROM 4 HUMAN TUMORS PROPAGATED IN IMMUNE-SUPPRESSED MICE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (2) , 390-392
Abstract
Two recently developed clonogenic assays for human tumor cells were used to measure the in vitro radiation cell survival of 4 human tumors, a pancreatic carcinoma, a colonic carcinoma, an oat cell carcinoma of the lung and a melanoma, propagated as xenografts in immune-suppressed mice. The slopes and shoulders of the survival curves for the first 3 tumors were similar with D0, respectively, of 94, 100 and 131 rads and with Dq, respectively, of 8, 44 and 41 rads. Melanoma cells from the 4th tumor had a survival curve that differed from those of the other 3, in having a wider shoulder with a Dq of 216 rads and having a shallower slope with a D0 value of 183 rads. The wide shoulder to the melanoma cell survival curve may explain the poor response to small fractionated doses of radiotherapy usually observed clinically for this tumor type. Data from the other 3 tumors suggest that differences in radiotherapeutic response seen in the clinic for these tumors cannot be attributed to differences in intrinsic radiosensitivity of the tumor cells.

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