PERITONEAL-DIALYSIS CLEARANCE OF CIMETIDINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 71  (6) , 572-576
Abstract
Peritoneal dialysis clearance of cimetidine [an H2 receptor antagonist] was determined in 2 patients undergoing peritoneal dialysis treatment. The peritoneal dialysis clearance of cimetidine was approximately 10 ml/min under optimal dialyzing conditions. The average cimetidine to creatinine extraction ratio was 0.45, which represents significant peritoneal dialyzability. The amount of cimetidine removed constituted only a small fraction of the total administered dose. Only minor dose adjustments may be necessary during peritoneal dialysis treatment. Cimetidine has been successfully used in the treatment of peptic ulcer disease, Zollinger-Ellison syndrome, esophagitis, upper gastrointestinal bleeding and metabolic alkalosis induced by nasogastric drainage.

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