Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation
- 1 September 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 139 (s52) , 8-11
- https://doi.org/10.1046/j.1365-2133.1998.1390s2008.x
Abstract
Adapalene and tretinoin are molecules used in the topical treatment of acne vulgaris. Commercial formulations (adapalene 0·1% gel and tretinoin 0·025% gel) were mixed with equal volumes of commercially available benzoyl peroxide formulation (10% lotion) and subsequently exposed to light over 24 h. With and without exposition to light, adapalene exhibits a remarkable stability whereas tretinoin is very sensitive to light and oxidation. The combination of benzoyl peroxide and light results in more than 50% degradation of tretinoin in about 2 h and 95% in 24 h.Keywords
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